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What is an important step to prove something is valid or not? determining the reliability observing research testing

Matching: 1. first used by europeans as a local anesthetic; now abused for its euphoric effects 5 marijuana 2. found in coffee beans, tea leaves, and cocoa beans 2 heroin 3. prescribed for pain involving serious injury or surgery 1 morphine 4. illegal derivative of morphine that is sold on the street as a white powder 6 caffeine 5. can evoke feelings of terror and panic 4 lsd 6. causes user to experience a conscious dreamlike state 3 cocaine

How does the way a persons brain function affect their mental health?