A drug fitting a one-compartment model was found to be eliminated from the plasma by the following pathways with the corresponding elimination rate constants.
Metabolism: km = 0.200 h- 1
a. What is the elimination half-life of this drug?
b. What would be the half-life of this drug if biliary secretion was completely blocked?
c. What would be the half-life of this drug if drug excretion through the kidney was completely impaired?
d. If drug-metabolizing enzymes were induced so that the rate of metabolism of this drug doubled, what would be the new elimination half-life?
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