When you misuse substances, like prescription opioids, what are two long-term risks?

Misusing opioids can lead to:

Decreased respiratory function, brain damage, death, and coma’s

No because males don’t have reproductive organs dummy

Smoking damages the respiratory system by inhalation of a foreign substance, that is absorbed and residue is left behind on our lungs sponge like substance. the gas that is inhaled also increase your blood pressure and dilates your blood vessels. also the process of inhaling and exhaling the smoke it causes irritation to the throat and mouth. smoking can cause lung cancer and other respiratory and circulatory diseases.