Is a state of physical and emotional exhaustion that includes a hopeless feeling, chronic fatigue, and low energy.

Depression is a state of physical and emotional exhaustion which includes a hopeless feeling, chronic fatigue, and low energy. People who experience depression often have hormonal imbalance in their body which causes the said side effects. Depression is often associated with constant changes in mood, withdrawn behavior or sometimes violent behaviors, and the inability to react to stimulus with a positive attitude. Depression can be cured through the practice of psychosis. An individual should always seek the help of professionals to address this disorder. If left untreated, some individuals often commit suicides and die of sadness.

It would be b. distress