Researcher has shown that the risk for neural tube defect is lowered by taking supplement

Yes

Idon’t really understand your questions

The person who utilize the progression principle will keep adding the difficulty of the exercise that he's doing, while the person who does not, will only stay stagnant.  the person that utilize progression principle, will get a stronger endurance because now his body is conditioned to do harsher routines.{the answer was already on verified)