How did the estuary at the mouth of the thames london become a center of trade?

It allowed ships to reach far inland.

Explanation:

The Thames has been very significant for the development of London as a financially and culturally important metropolis. The river provided water to people, encouraging the first settlements. It also provided a route for trade to be achieved. In terms of trade, the estuary at the mouth of the Thames was also important because it allowed ships to reach far inland, which contributed to commerce.

the answer is flapper.

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