What ethical issues did humanists struggle with during the italian renaissance?

Humanists struggled to find answers to man's fundamental questions and moral dilemmas that were based in human nature, rather than the divine.

worcester v. georgia, legal case in which the u.s. supreme court on march 3, 1832, held (5–1) that the states did not have the right to impose regulations on native american land. andrew jackson refused to enforce the ruling, the decision form the basis for most subsequent indian law in the united states.