How did the fact that the safavids were shiite muslims affect relations with the ottomans?

The Safavid Empire´s religion was Shi'a Islam and all other religions, and forms of Islam were prohibited.  

For over a century the Ottoman Empire and Safavid Persia fought over the control of the South Caucasus and Mesopotamia and dogmatic disputes: the Ottomans were Sunnis and believed the Shia Muslims of the Qizilbash sect were heretics.

you aint got nothin on my lil weenies

after a more than a decade and a half of combating al qaeda (aq) in afghanistan and pakistan,

the united states faces a diverse array of threats from al qaeda affiliates in the middle east and

africa. while senior al qaeda figures reportedly remain based in pakistan, the network includes

a number of affiliates across the middle east and africa including al qaeda in the arabian

peninsula (aqap), al qaeda in the islamic maghreb (aqim), and al shabaab. al qaeda also

retains a small but possibly growing presence in afghanistan. u.s. officials have stated that al

qaeda still maintains a foothold in syria through its ties to hay’at tahrir al sham (formerly

known as the nusra front), though the exact nature of that relationship may be evolving. this

report examines the threat posed by al qaeda affiliates in the middle east and africa as described

by u.s. officials and outside observers, as well as the u.s. approach to date in responding to these

threats. this was all i could find hope this : )