Which of these had the most direct impact on the native americans great plains

Which document did the second continental congress send king george iii to refaffirm colonist allegiance to him but not to parliament

Which of the following arguments decided the debate over using the atomic bomb against japan in 1945? using the bomb would destroy the armaments still available to japanese forces in japan. using the bomb would demonstrate the power of the united states to the entire world. using the bomb would shorten the war and avoid heavy casualties among invading troops. using the bomb would enable allied forces to invade and take over the japanese mainland

What from the columbian exchange had perhaps the biggest impact on the world?