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explain the aspect of exploration and colonization that had the greatest impact on the native peoples of north and south america?

In both North America and South America, the european conquest was a disaster for the indigenous people because of the dissemination of diseases of european origin, such as influenza, smallpox and measles, for which they didn't have defenses.

These diseases wiped out about 95% of the native american population. In fact, some reaserchers have argued that the loss of native american life was so big that it actually resulted in a brief period of global cooling.

were at first enthusiastic in support of the revolution. however, over time divisions of opinion became apparent between federalists and anti-federalists

yellow fever and other tropical diseases