What accounted for the majority of deaths in spanish america in the 16th century?
a) small pox
b) tribal wars
c) military conquest
d) natural disaster

Small pox accounted for the majority of deaths in Spanish America in the 16th century. The correct option among all the options that are given in the question is the first option or option "A". During those days, there were no vaccines against small pox and it spread very quickly. I hope the answer helps you.

Spanish conquistadors demanded labour from natives.