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The Columbian Exchange had begun prior to the discovery of the new world.

Explanation:

The most important instant consequence of the  Exchange of  Columbia   was beneficial. Various shrubs local to the Americas have radiated about the world, supported by the New World discovery of quinine, the first powerful practice for malaria. A large result of the beneficial trade-offs involved yielding habits and traditions. The  Exchange of Columbia , called as the Columbian interchange, called after Christopher Columbus, was the general transference of flowers, invertebrates, culture, human populations, technology, viruses, and  concepts within the Americas, Western part of  Africa, and the Ancient World.

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