What inspired the 1715 uprising by the Yamasee and Creek peoples against English colonists in Carolina?

High debts incurred by the Yamasee and Creek in trade with the English settlers

Explanation:

The conflict that occurred between the British Settlers of Carolina and   confederation of Native American people ( Cherokee, Muskogee etc. ) is known as Yamasee War, it lasted from 1715 till 1717.

The war started when the Native confederation attacked the white settlements in South Carolina, later the tide turned against the Natives and they were defeated by the colonialists and they got the control over the coast of South Carolina, the natives were pushed onto the land of northern Florida.  

The native Indians incurred debt because they the tribe had become dependent on the English firearms and other items  and incurred a large debt because of it, the had to be paid in form of deerskins. the white fur traders enslaved a  number of Yamasee children and women to cover their debt.  The influx of white settlers also put pressure on the Indian hunting and agricultural lands.

the answer is selfishly. hope this !