Why early colonial North America developed into three distinct regions?

As the tide of the seven years’ war (french and indian war) turned in britain’s favor, the iroquois

In the mid-1800s, native americans who had lived in the westtraded their manufactured goods with settlers.were able to resist diseases carried by settlers.offered their services as guides to settlers.prevented settlers from moving onto their territory.

When conducting research for forming a hypothesis, which practice should historians follow?