What factors that existed/occurred that contributed to growing resentment/hatred of Jewish people in Europe?

The term anti-Semitism was first popularized by German journalist Wilhelm Marr in 1879 to describe hatred or hostility toward Jews. The history of anti-Semitism, however, goes back much further.  Hostility against Jews may date back nearly as far as Jewish history. In the ancient empires of Babylonia, Greece, and Rome, Jews—who originated in the ancient kingdom of Judea—were often criticized and persecuted for their efforts to remain a separate cultural group rather than taking on the religious and social customs of their conquerors.

the enslaved people onboard suffered from illness with some frequency