Who was in charge of knowledge prior to the 1500s?

Scholars

Explanation:

Today the relevance of scholars is not as important as it used to be prior to the 1500s when they were the custodians of knowledge.

In those days scholars as the intellectuals of the day were given the role and responsibility of maintaining the knowledge of society and as such they were referred to when issues of right and wrong arose. They would then offer opinions on these issues based on the wealth of knowledge at their disposal including ancient texts and religious sources like the Bible and the Quran.

the answer is 250 percent.

the doctrine of nullification recommended that states living inside the union have the one-sided, inalienable ideal to void any law made by the national government that could be esteemed illegal.

the united states was shaped based on a general agreement among its individual states. hence, it is inferred that under the hypothesis of invalidation, since the states are the establishment of the union, they have the ability to referee and disprove unlawful laws.