All of the following were significant challenges faced by the Cherokee on the Trail of Tears except A. constant illness and starvation
B. long forced migration on foot
C. exposure to harsh temperatures
D. attacks from Osage tribes

The correct answer would be D, attacks from Osage tribes.

Explanation:

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the dominoes began to fall. the surrender at appomattox took place a week later on april 9. while it was the most significant surrender to take place during the civil war, gen. robert e. lee, the confederacy's most respected commander, surrendered only his army of northern virginia to union gen. ulysses s. grant

explanation:

travels along an axon. this triggers a wave of electrical activity that passes from the cell body along the length of the axon to the synapse