What was the main reason many Southern states
chose to seceed from the Union?

Slavery

Explanation:

The direct cause was Abraham Lincoln, a Republican president being elected, which caused South Carolina to secede and the rest of the southern states followed. The long term reasons were of course the issue of slavery. The southern states wanted to transport their slaves anywhere in the country, and felt that their interests would be threatened if Abe Lincoln was elected.

religion was the center of there society they practiced human sacrifices and which they believed kept there god strong and that he would keep bad guys away hope this