Which of the following are the states that dominated the Mediterranean trade during the sixteenth century? a) Italian city-states and the Ottoman Empire
b) The Byzantine Empire and the Ottoman Empire
c) Spain and Portugal
d) The Hapsburg Empire and France
e) The Crusader states

What is the columbian exchange? o a. the changes that resulted from europeans settling in the new world b. the relationships that columbus and his men had with the natives they met o c. the ships that columbus bought with money from the king and queen of spain o d. the increase in the number of native american towns in the new world