What did Columbus unintentionally do to Native American cultures

Christopher Columbus carried ideas that boded ill for Indies natives. ... "I am the saddest man in the world," he wrote, "because I do not recognize them." ... The Great Khan, whose empire stretched from the Arctic to the Indian Ocean, had displayed to ... of the invaders, for self-denial was an ancient virtue in Western culture.

Explanation:

the main reason that the constitution did not proclaim all men to be free and equal is because of the issue of slavery.

a flatwork hope this