Which of the following are true of the Midwest Region? You may choose more than one answer. The Great lakes are to the east. The Midwestern states are located in the north and central part of the United States. The country of Canada is to the north of these states. The southern states are to the south, while the Mountain states are to the east. Which of the following are true of the Midwest Region? You may choose more than one answer. The Great lakes are to the east. The Midwestern states are located in the north and central part of the United States. The country of Canada is to the north of these states. The southern states are to the south, while the Mountain states are to the east.