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the enslaved people onboard suffered from illness with some frequency

the correct answer is “opportunity cost”. opportunity cost is what a company misses out because it decided in one option over another one. in this case, the company decided to invest in building a factory so it gave up another possible benefit or profit in order to achieve success with the factory.  

trade-off is not the correct answer since it is a situation in which you accept losing something in return for benefits in other areas.

and finally, consequence is a general term used to accept what it comes when you make a decision. it can be a positive or negative consequence depending if the decision you took was the correct one.