How did geographic differences between regions lead to economic differences between them

president jefferson protested this interference in american trade. he sent james monroe to london to negotiate a treaty. jefferson wanted britain to stop taking sailors from american ships, and to stop interfering in the trade of neutral nations. monroe tried many times to discuss such an agreement. but the british foreign minister was always too busy to see him.

explanation:

disease was the number one killer of native peoples. they had had little exposure to the diseases of europe. this led to some villages being almost completely wiped out and some tribes destroyed.