Which of the following reasons explains why smallpox had such a devastating effect on the inca and aztec populations?

a. the disease affected only men and destroyed the armies of the empires.
b. the disease gave them a false feeling of strength when they were weak.
c. the people did not have immunity against the disease.
d. the people had already been hit by pandemics before the europeans arrived.

The people did not have immunity against the disease.

The Inca and Aztec peoples were developed societies in the central and southern americas. These people lived only in their territory and did not have antibodies with the antigens present in the bodies of the Europeans. Thus, unintentionally, the white man transmitted the smallpox virus to these communities, which were practically decimated by the disease. When a society is isolated, such as the Incas and Aztecs, a seemingly harmless antigen can cause devastation, precisely because people still do not have antibodies to fight the disease.

i believe it was spain

this is a good question! i'll do some research and come back when i have the answer!