How did the Indian Removal Act impact the growth of slavery in the South?

Native Americans "owned" large plots of land for their villages, and once removed from their land it allowed plantation owners to buy the land, this new land on the plantations meant there would be a need for more slaves.

Removed potential slaves / Allowed for more farms to be built on sacred land

Explanation:

When the natives were removed from the southern colonies, people weren't able to enslave and force work upon the tribes there, this would result in farmers requiring slaves to be purchased from continents such as Africa. Since all the natives were forced out of the area this also left their land open. With all this new land available for farmers the need for slave workers increased with it.