The last great persecution of christians was ordered by

freedom of speech is also protected by the 1 amendment.

explanation:

here is pretty much what the 1st amendment says:

congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the government for a redress of grievances.

the option which was not a function of missionaries in the northwest was the first one - they established posts for trading furs and other goods.

missionaries were sent around the world to spread religion and their knowledge and others - they were not merchants who sold furs and other goods.