Where did spain suffer its greatest setback at the hands of native americans?

The Spain has suffered its greatest setbacks at the hands of the Native Americans called the Aztecs. The Aztecs were known to dominate the states that were close to them in which they also permits their ruler in having to impose their ideals and as well as their religion. 

he ottoman empire established islam as its guiding religion, government, and laws

a more perfect union: the creation of the u.s. constitution. the vote was unanimous. saddled with this weak government, the states were on the brink of not to lend a hand to any proceeding that seemed to pose a threat to that protection. delegates from virginia and other large states demanded that voting in