The anti-federalists’ main objection to ratifying the constitution was that it

The Anti-Federalists’ main objection to ratifying the Constitution was that it would place too much power in the hands of the federal government over the individual states. This is why they insisted on a "Bill of Rights" to be added to the Constitution to protect individual liberty. 

The case was a u.s. supreme court decision that defined the scope of the u.s. congress's legislative power and how it relates to the powers of american state legislatures. the dispute in mcculloch involved the legality of the national bank and a tax that the state of maryland imposed on it.

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