Can someone answer #7 . you dont need to solve it i just need the equation! (algebra 2)

The vertex of this parabola is at (-2,-3). when the x-value is -1, the y-value is -5. what is the coefficient of the squared expression in the parabola's equation?

Apatient is to be given 35 milligrams of demerol every 4 hours. you have demerol 50 milligrams/milliliter in stock. how many milliliters should be given per dose?

Last one and the bottom answer choice is y=(x-4)^2+1 you guys!