What happens when you add a positive and a negative number together

Could somebody me with this radical simplification?

Apatient is to be given 35 milligrams of demerol every 4 hours. you have demerol 50 milligrams/milliliter in stock. how many milliliters should be given per dose?

When george started his current job, his employer told him that at the end of the first year, he would receive two vacation days. after each year worked, his number of vacation days will double up to five work weeks (25days) of payed vacation. how many vacation days will he have in 4 years