HELP I GIVE BIG BRAIN!!! see attachment

Alicense plate is to consist of 44 digits followed by 55 uppercase letters. determine the number of different license plates possible if the first and second digits must be? odd, and repetition is not permitted.

Find the slope of the line that contains the following points. r(-2, 4), s(6, -2)

Ineed if you could explain and give me the answer you! this needs done