15. A major driving force for protein folding is the hydro phobic effect, in which hydrophobic amino acid side chains tend to cluster together, usually in the core of globular
proteins. This occurs primarily due to which of the following?
(A) Increasing hydrogen bond formation
(B) Increasing the entropy of water
(C) Increasing disulfi de bond formation
(D) Minimizing van der Waals interactions
(E) Reducing steric hindrance between amino acid side chains