1. Researchers have discovered the gene that causes migraines. This gene called TRESK is believed to control the sensitivity of pain nerves In the brain. If this gene is faulty, the pain threshold of nerves is lowered. You have developed a drug called Imatresk you believe will shut
off this gene and relieve the pain of migraine sufferers. You tested the drug on the four people below after successful animal trials. After
one treatment, Susie no longer suffers from migraines. Bill's and Fred's migraines have decreased in intensity but they still get them. One
more dose of Imatresk should stop the migraines. Jenny still suffers intense migraines with no relief. You decide to send a sample of
each patient's blood out for DNA sequencing. If you can analyze the sequence for the TRESK gene, the segment of DNA that controls
nerve pain in the brain, perhaps you can find a clue that may explain the varied response to the migraine drug.
2
Jenny т т т т т А с A G с а с A G A A т с т т т с т
BILI
Susie
т т т т т А с A a та с A G A A т с т т т с т 725
т т т т т А с A G та с A G А А т с т т т с т
т т т т т А с A G са с A G А А т с т т т с т
Fred
л
Jenny с т а т а т т т с т т т с т т А та А с с с А
BIII с та та т т т с т т т с т т А та А с с с A 850
Susie G т а т а т т т с т т т с т т А T G A т с с А
Fred о то то т т т с т т т с т т А та А т с с А
Analyze the DNA sequences above and complete the following:
1. Determine which base pair numbers that SNPs/differences in the DNA between the patients occur.
2. List the SNP Profile (the nucleotides) for each patient in the study. .
3. Explain WHY Jenny does not respond to Imatresk.

Discuss the 2 major types of diabetes insipidus (central and nephrogenic).

Harold, a fifty-eight year old grocery store manager, had recently been waking up in the middle of the night with abdominal pain. this was happening several nights a week. he was also experiencing occasional discomfort in the middle of the afternoon. harold decided to schedule an appointment with his physician. the doctor listened as harold described his symptoms and then asked harold some questions. he noted that harold's appetite had suffered as a result of the pain he was experiencing and as a result of the fear that what he was eating may be responsible for the pain. otherwise, harold seemed fine. the doctor referred harold to a physician that specialized in internal medicine and had harold make an appointment for a procedure called an endoscopy. the endoscopy was performed at a hospital later that week. during the procedure, a long, thin tube was inserted into harold's mouth and directed into his digestive tract. the end of the tube was equipped with a light source and a small camera which allowed the doctor to observe the interior of harold's stomach. the endoscope was also equipped with a small claw-like structure that the doctor could use in order to obtain a small tissue sample from the lining of harold's stomach, if required. the endoscopy revealed that harold had a peptic ulcer. analysis of a tissue sample taken from the site showed that harold also had an infection that was caused by helicobacterpylori bacteria. the doctor who performed the endoscopy gave harold prescriptions for two different antibiotics and a medication that would decrease the secretion of stomach acid. the doctor also instructed harold to schedule an appointment for another endoscopy procedure in 6 months. 1. list the subjective findings in this case study. 2. what is an endoscopy? (2 points) what is a biopsy? 3. how was a biopsy performed on harold? 4. differentiate between gastric and duodenal ulcers by location. 5. what role does h. pylori play in the formation of peptic ulcers? 6. define occult and frank blood. (4 points) what is a guaiac test? 7. how can peptic ulcers cause bleeding? 8. why were antibiotics prescribed? 9. why would a medication that would decrease the secretion of stomach acid be beneficial?

Anurse is instructing a client who has a new prescription for a daily dose of lovastatin extended release. which of the following information should the nurse include in the teaching? a. report to the clinic for quarterly monitoring of kidney function while taking this medication. b. mix with applesauce after crushing if the medication is difficult to swallow. c. avoid consuming dairy products while taking this medication. d. take the medication with the evening meal.