An energetic graduate student decides to do a voltage clamp experiment in which she clamps a single voltage gated-sodium channel and holds it at voltages ranging from -100 to +100 mV. Which of the following is she likely to observe? Assume ENa+ = +50 and EK+ = -70.
a. Sustained inward currents lasting several milliseconds would be detected from -100 to +100 mV
b. Transient inward currents of about 2 pA would be detected from -100 to +100 mV, but would be smallest in amplitude close to +50mV
c. Transient outward currents would occur at +70mV Correct
d. Transient currents would last longer and longer as the voltage was increased from +10 to +60 mV
e. None of the above
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