What are close-toed shoes least likely to provide protection against?

gasses can permeate into shoes, therefore close tied shoes are less likely to defend against hydrogen gas generated during a reaction.

Explanation:

In any chemical laboratory It is also necessary to protect one feet together with a proper lab coat. Closed toe shoes also offer security from leaked water from the hot water pool, broken glass from the test tube, and acid leakage from a damaged bottle.

On other side, gasses can permeate into shoes, therefore close tied shoes are less likely to defend against hydrogen gas generated during a reaction.