What is the mysterious mark on declaration of independence

A handprint on the bottom left corner.

Explanation:

It isn't known who left the mark, as the document was rolled, bagged, and transported by wagons and ships.

 The correct answer is :  The mark is a handprint in the lower left.

Explanation:   It is not known with certainty how this imprint came to the declaration of independence, but some historians believe that it was because it was handled very informally in the first days of the republic. Since its signature in 1776 the document has been transported without precaution throughout the country, in carriages, on sailboats and an unprotected car.

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explanation:

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