Continuing review of an approved and ongoing study posing more than minimal risk that was initially approved by a convened irb:
a. is not required unless additional risks have been identified.
b. is limited to review of unanticipated problems.
c. must occur within 12 months of the approval date.
d. must be conducted by a convened irb.

Early 18th century british industries were generally small scale and relatively unsophisticated. most textile production, for example, was centred on small workshops or in the homes of spinners, weavers and dyers: a literal ‘cottage industry’ that involved thousands of individual manufacturers. such small-scale production was also a feature of most other industries, with different regions specialising in different products: metal production in the midlands, for example, and coal mining in the north-east.two illustrations of 18t