Does seeking a personal philosophy of the meaning of life-grapple with such questions as "How do I know that what I believe is true?",

Yes. A personal philosophy of the meaning of life speaks to the tough questions, one of which could seek to establish the veracity of our beliefs.

"Where do we come from?"

"How do we know what happens after death?"

"What is the purpose of life?"

"How is it that the narratives about the origin of life are plagues with so much contention and controversies?"

The above are some examples of deep philosophical questions which deepen the knowledge we have about the meaning of life.

Cheers!

answer; the smaller of the two reciprocal products of translocated chromosomes is lost; after several cell divisions, only the larger of the two translocated chromosomes remains,its reciprocal is lost;