The virginia company chose the inland site for jamestown because it was
1. not controlled by the powhatan american indians.
2. easy to defend from the spanish.
3. easy to defend from american indians.
4. on a river that did not have swamps.

Option: 2. Easy to defend from the Spanish.

Explanation:

When the Virginia Company decided to send settlers in New World for establishing Jamestown colony, they knew that they were not the only European in America. England did not have any good relationship with other European states since the reign of Elizabeth I of England. The Virginia Company advised settlers to select a location that could quickly defend itself from attacks by other European states like Spain, Dutch, and France.  

when the united states took over

i think the answer is true : ))