Suppose you have binding of a certain Kd. If you wanted to change the molecule so it bound more tightly you might have an effect either on the "on rate constant " or the "off rate constant" or both. To increase affinity how these rate constants need to change? Drugs normally act by binding to some receptor or enzyme. Suppose a drug is given so that its concentration in cells is around the Kd for the ligand that it binds to. How much more effect could you expect if you gave 10X as much drug. What else might you expect to happen

When in college, greg dreamed of rowing in the olympics and becoming a surgeon. now at age 48, he continues to enjoy rowing, although he never made it to the olympics and he works as an anesthesiologist. his wife and kids are healthy and he is basically content. according to erikson, he is most likely to experience

You are an faa-certificated air traffic control tower operator employed by the faa in that position. you are required to also hold a current faa aviation medical certificate to exercise the privileges of your certificate. your current medical certificate expires tomorrow and you're online filling out the faa application form to get a new medical certificate, when you come to the question: "do you currently use any medication (prescription or nonprescription)? " you've been under a lot of stress lately at home, mainly caused by family finances, and were feeling pretty depressed. sensing your mental state, your brother-in-law gave you a bottle of prescription anti-depressant tablets, saying: "here, try these; they really worked for me when i was all down about losing my job last year and i don't need them anymore." you tried them, they are working, and you're feeling fine now that you're taking them. there's no record of you getting the meds, and you consider answering the question "no" to avoid the possibility of a truthful answer causing problems for you at work. describe in detail all of the possible adverse legal consequences you would be risking if you give that false answer.

The development of simple stone tools by early hominids led to the ability to procure meat more efficiently. this in turn led to the change in diet that included larger amounts of protein. many scholars believe that this shift in diet was a significant part of how our ancient ancestors adapted so quickly to a varied set of environments, and thus were able to begin cultural development. this demonstrates the intimate connection between