This was the 1715 to 1717 conflict that took place on the south carolina frontier between a coalition of indian tribes and the british colonists and that resulted in the deaths of hundreds of colonists and indians, as well as the destruction of many frontier towns.

The Yamasee War

The Yamasee War started in 1715 in British America. It was a conflict between the Yamasee Indians of South Carolina and British colonists. The war led to the end of Indian dominance in the area. The Yamasee had several Indian allies, such as the Cherokee and the Lower Creek. However, the colonists also allied themselves with settlers from nearby towns and eventually defeated the Native Americans.