¿qué hora es? son las once y cuarenta y cinco de la noche.

This would be translated to:

What time is it? 
It is 1:45 PM.

This is because:

Que Hora Es

Que translates directly to what, hora, time, es, is.

What time is it? is the translation.

Son las once y cuarenta y cinco de la noche.

Son translates to It, las is basically is, once is one, y cuarenta, is and forty, y cinco, and five, de la noche, in the night.

So basically, It is one and forty and five in the night, or It is 1:45 in the night.

What’s your favorite video game, is the translation.