The consequences of chronic cocaine abuse include

a. narcolepsy
b. heart failure and coughing up blood
c. paralysis and loss of limbs

B. Heart failure and coughing up blood

Explanation:

Cocaine is mostly used as a recreational drug which is a strong stimulant. There are various methods that are used to administer cocaine into the body they include snorting, inhaling as smoke, or dissolving and injecting into a vein.

Strong imbalances of transmitter levels in order to compensate extremes is caused by chronic cocaine intake. The mode in which the receptors work changes from off to working mode, or the binding partners mechanisms changes called downregulation and upregulation.

you are certainly talking about this picture:

a: is the label of the white square, it is showing the  replication fork, formed by helicase (d) ==> so it is the site of dna separation and replication 

b: is a new dna brand that is following directly the replication fork, so it is continuous ==> built continuously from 5' to 3

c: dna polymerase cannot replicate dna on its own, it needs the of their proteins, and one of them plays the role of a clamp which fixes  the dna with the dna template and increases  the processivity of the enzyme. ==>   stops polymerase from falling off the  template.

d: is the enzyme responsible for forming the replication fork (helicase) ==> unwinds and separates dna into two strands

e: is the delayed strand, it is built  in the opposite sense of the helicase, so dna will be built in fragments ==> built  fragments from 5' to 3 joins

and finally f: is the enzyme that builds  the new dna strand (dna polymerase) ==>   adds nucleotides to make a new dna helix.

credit: gradman555p98x9p

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