Endocrine signals are transmitted more slowly than paracrine signals because
the ligands are transported through the bloodstream and travel greater distances
the target and signaling cells are close together
the ligands are degraded rapidly
the ligands don't bind to carrier proteins during transport

The ligands are transported through the bloodstream and travel greater distances

Explanation:

Endocrine signal are transmitted slowly as compared to paracrine signal as, the ligands are interact with the proteins in the cells and transported through the bloodstream and it traveled grater distance.

In the paracine signalling the ligands are transported nearby the cells, then the cells are close to each other. Therefor the signal traveled faster.

In the endocrine gland, the ligands are not rapidly degraded.

Ligands bind the molecules of receptor in the target membrane.

So, that is why the option first are correct.