How could large molecules cross the cell mebrane

When molecules are too large or too charged to cross the plasma membrane by diffusion or osmosis, there are other methods to accomplish their transport into or out of the cell. For example, some proteins in the plasma membrane are known as protein channels and they form a way for large or charged molecules to pass through the membrane.

Explanation:

cellular respiration oxidizes food into energy in the form of atps.

glycolysis (6 c hexose) > 2x atps are used > 6c hexose biphosphate > 2 x 3c triphosphate >

2 x 3c pyruvate (2x nadh produced from nad) and (4x atp produced)

pyruvate actively pumped mitochondrial matrix.