Mitosis & Cell Cycle Cell Cycle: A repetitious event Two Main areas: and Interphase : Cell increases in size, prepares for DNA copying Synthesis: DNA gets (2 copies of DNA) Growth 2: Cell grows more, make more proteins, replicate Mitosis: Cell Mitosis in depth phase of the cell cycle Many things going on in the cell One cell becomes two Virchow “Every cell comes from a pre-existing cell” Four main phases: Prophase, Metaphase, Anaphase, Telophase Prophase phase of mitosis Chromatin coils up into visible chromosomes (sister chromatids) Connected by a centromere Nuclear envelope and nucleolus Centrioles migrate to opposite ends of the cell form between centrioles Metaphase Short second phase of mitosis Spindle fibers attach to centromeres and move chromatid sisters to the of the cell Anaphase Shortening of the spindle fibers pulls chromatid sisters . separate and go to opposite ends of the cell Telophase Final phase of mitosis Chromatids are at (ends) of the cell Spindle fibers break down, new nucleus and nucleolus start to reappear Double membrane begins to form between nuclei Cytokinesis