In arthritis, there is deposition of urate crystals in joints. If you want to treat the arthritis by decreasing the concentration of circulating uric acid, what will you do with its mechanism in kidney?

Answer and explanation:

If I'd wanted to decrease the concentration of circulating uric acid by altering its mechanism in the kidney, I would administer a drug that would inhibit uric acid reabsorption and increase its excretion through urine.

Arthritis is a condition characterized by inflammation of the joints and can be caused by many diseases. When the cause of this arthritis is the deposition of urate crystals in the joint because of an increase in the concentration of circulating uric acid (hyperuricemia) we are most likely talking about gout, a painful disease that can deform the joints.

Hyperuricemia and gout have many risk factors associated with them, such as genetic predisposition, unhealthy diet, and suffering from other conditions like Diabetes.

Several medications are used in the treatment of the symptoms and the prevention of the worsening of this disease, but the one that is most frequently used to increase the excretion of uric acid is Probenecid. Probenecid blocks the kidney's OAT (organic anion transporter) that reabsorbs uric acid in the kidney tubules, thus enhancing its excretion and decreasing uric acid's blood concentration.

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