During DNA replication, the strand is synthesized in the 5′ to 3′ direction. The strand that runs away from the replication fork is synthesized because.

during the process of dna replication, brdu can replace thymidine and incorporate into the newly synthesized dna, cell proliferation thus can be reflected in the extent of brdu incorporation.

yes, because even though a theory has a  lot of evidence to support it, it is not always true