Given this, what advantage might be offered by having a code with 64 codons? given this, what advantage might be offered by having a code with 64 codons? an advantage of having more than the minimum number of codons is error tolerance. because of the redundancy in an expanded code, not every base pair change will change the meaning of a codon. an advantage of having more than the minimum number of codons is evident. as there are more codons, all amino acid sequences will be more varied. this will influence the three-dimensional structure, functions, and physical properties of proteins. there is no advantage of having more than the minimum number of codons. though the number of amino acids which can be coded will increase, mistakes during translation will become more frequent as well. submitrequest answer