An experimenter studying the oxidation of fatty acids in extracts of liver found that when palmitate (16:0) was provided as substrate, it was completely oxidized to CO2. However, when undecanoic acid (11:0) was added as substrate, incomplete oxidation occurred unless he bubbled CO2 through the reaction mixture. The addition of the protein avidin, which binds tightly to biotin, prevented the complete oxidation of undecanoic acid even in the presence of CO2, although it had no effect on palmitate oxidation. Explain these observations in light of what you know of fatty acid oxidation reactions.

Even-number fatty acids such as palmitate undergoes complete β-oxidation in the liver motochondria to CO₂ because the product, acetyl-CoA can enter the TCA cycle.

Oxidation of odd-number fatty acids such as undecanoic acid yields acetyl-CoA + propionyl-CoA in their last pass. Propionyl-CoA requires additional reactions including carboxylation in order to be able to enter the TCA cycle.

The reaction CO2 + propionyl-CoA > methylmalonyl-CoA is catalyzed by propionyl-CoA carboxylase, a biotin-containing enzyme, which is inhibited by avidin.  Palmitate oxidation however, does not involve carboxylation.

Explanation:

Even-number fatty acids such as palmitate undergoes complete β-oxidation in the liver motochondria to CO₂ because their oxidation product, acetyl-CoA, can enter the TCA cycle where it is oxidized to CO₂.

Undecanoic acid is an odd-number fatty acid having 11 carbon atoms. Oxidation of odd-number fatty acids such as undecanoic acid yields a five -carbon fatty acyl substrate for their last pass through β-oxidation which is oxidized and cleaved into acetyl-CoA + propionyl-CoA. Propionyl-CoA requires additional reactions including carboxylation in order to be able to enter the TCA cycle. Since oxidation is occuring in a liver extract, CO₂ has to be externally sourced in order for the carboxylation of propionyl-CoA to proceed and thus resulting in comlete oxidation of undecanoic acid.

The reaction CO2 + propionyl-CoA > methylmalonyl-CoA is catalyzed by propionyl-CoA carboxylase, a biotin-containing enzyme.  The role of biotin is to activate the CO₂ before its tranfer to the propionate moiety. The addition of the protein avidin prevents the complete oxidation of undecanoic acid by  binding tightly to biotin, hence inhibiting the activation and transfer of CO₂ to propionate.

Palmitate oxidation however, does not involve carboxylation, hence addition of avidin has no effect on its oxidation.

"the periodic table is arranged in order of atomic number."

i think that the answer is c